import sys
import os
import re
import unicodedata
import operator
import math
from collections import defaultdict, namedtuple
from operator import itemgetter
from functools import reduce
from xml.sax.saxutils import escape

from contextlib import contextmanager

from AnyQt.QtWidgets import (
    QFrame, QHBoxLayout, QPlainTextEdit, QPlainTextDocumentLayout,
    QCompleter, QListView, QTreeView, QAction, QToolButton, QRadioButton,
    QButtonGroup, QMenu, QDialog, QStackedWidget, QComboBox, QFileDialog,
    QStyle, QStyledItemDelegate, QStyleOptionViewItem, QStyleOptionButton,
    QApplication
)
from AnyQt.QtGui import (
    QSyntaxHighlighter, QTextCursor, QTextCharFormat, QTextDocument,
    QStandardItemModel, QStandardItem, QPalette, QColor
)
from AnyQt.QtCore import QSortFilterProxyModel, QItemSelectionModel
from AnyQt.QtCore import Qt, QEvent, QThread, Signal

import Orange

from Orange.widgets import widget, settings, gui
from Orange.widgets.utils.concurrent import (
    ThreadExecutor, Task, methodinvoke
)

from Orange.widgets.utils.itemmodels import VariableListModel
from Orange.widgets.utils.datacaching import data_hints

from orangecontrib.bio import taxonomy
from orangecontrib.bio import gene as geneinfo


class SaveSlot(QStandardItem):
    ModifiedRole = next(gui.OrangeUserRole)

    def __init__(self, name, savedata=None, modified=False):
        super(SaveSlot, self).__init__(name)

        self.savedata = savedata
        self.modified = modified
        self.document = None

    @property
    def name(self):
        return self.text()

    @property
    def modified(self):
        return bool(self.data(SaveSlot.ModifiedRole))

    @modified.setter
    def modified(self, state):
        self.setData(bool(state), SaveSlot.ModifiedRole)


class SavedSlotDelegate(QStyledItemDelegate):

    def paint(self, painter, option, index):
        option = QStyleOptionViewItem(option)
        self.initStyleOption(option, index)

        modified = bool(index.data(SaveSlot.ModifiedRole))
        if modified:
            option.palette.setColor(QPalette.Text, QColor(Qt.red))
            option.palette.setColor(QPalette.Highlight, QColor(Qt.darkRed))
            option.text = "*" + option.text

        if option.widget:
            widget = option.widget
            style = widget.style()
        else:
            widget = None
            style = QApplication.style()

        style.drawControl(QStyle.CE_ItemViewItem, option, painter, widget)


def radio_indicator_width(button):
    button.ensurePolished()
    style = button.style()
    option = QStyleOptionButton()
    button.initStyleOption(option)

    w = style.pixelMetric(QStyle.PM_ExclusiveIndicatorWidth, option, button)
    return w


class OWSelectGenes(widget.OWWidget):

    name = "Select Genes"
    description = "Select a specified subset of the input genes."
    icon = "../widgets/icons/SelectGenes.svg"
    inputs = [("Data", Orange.data.Table, "setData", widget.Default),
              ("Gene Subset", Orange.data.Table, "setGeneSubset")]
    outputs = [("Selected Data", Orange.data.Table)]

    SelectInput, SelectCustom = 0, 1
    CompletionRole = Qt.UserRole + 1

    settingsHandler = settings.DomainContextHandler()

    geneIndex = settings.ContextSetting(0)
    taxid = settings.ContextSetting(None)
    subsetGeneIndex = settings.ContextSetting(-1)

    savedSelections = settings.Setting([
        ("Example", ["MRE11A", "RAD51", "MLH1", "MSH2", "DMC1"])
    ])
    selectedSource = settings.Setting(SelectCustom)
    selectedSelectionIndex = settings.Setting(-1)
    completeOnSymbols = settings.Setting(True)

    autoCommit = settings.Setting(False)
    preserveOrder = settings.Setting(True)

    want_main_area = False

    def __init__(self, parent=None):
        super().__init__(parent)

        # Input variables that could contain names
        self.variables = VariableListModel(parent=self)
        # All gene names and their symbols
        self.geneNames = []
        # A list of (name, info) where name is from the input
        # (geneVar column) and info is the NCBIGeneInfo object if available
        # or None
        self.genes = []
        # Output changed flag
        self._changedFlag = False
        # Current gene names
        self.selection = []
        # Input data
        self.data = None
        self.subsetData = None
        # Input variables that could contain gene names from "Gene Subset"
        self.subsetVariables = VariableListModel(parent=self)
        # Selected subset variable index

        self.organisms = []
        self.taxidindex = {}
        self.geneinfo = (None, None)
        self._executor = ThreadExecutor()

        self._infotask = None

        box = gui.widgetBox(self.controlArea, "Gene Attribute")
        box.setToolTip("Column with gene names")
        self.attrsCombo = gui.comboBox(
            box, self, "geneIndex",
            callback=self._onGeneIndexChanged,
        )
        self.attrsCombo.setModel(self.variables)

        box = gui.widgetBox(self.controlArea, "Gene Selection")

        button1 = QRadioButton("Select genes from 'Gene Subset' input")
        button2 = QRadioButton("Select specified genes")

        box.layout().addWidget(button1)

        # Subset gene variable selection
        self.subsetbox = gui.widgetBox(box, None)
        offset = radio_indicator_width(button1)
        self.subsetbox.layout().setContentsMargins(offset, 0, 0, 0)
        self.subsetbox.setEnabled(
            self.selectedSource == OWSelectGenes.SelectInput)

        box1 = gui.widgetBox(self.subsetbox, "Gene Attribute")
        box1.setFlat(True)
        self.subsetVarCombo = gui.comboBox(
            box1, self, "subsetGeneIndex",
            callback=self._onSubsetGeneIndexChanged
        )
        self.subsetVarCombo.setModel(self.subsetVariables)
        self.subsetVarCombo.setToolTip(
            "Column with gene names in the 'Gene Subset' input"
        )
        gui.button(box1, self, "Copy genes to saved subsets",
                     callback=self.copyToSaved)

        gui.button(box1, self, "Append genes to current saved selection",
                     callback=self.appendToSelected)

        box.layout().addWidget(button2)

        self.selectedSourceButtons = group = QButtonGroup(box)
        group.addButton(button1, OWSelectGenes.SelectInput)
        group.addButton(button2, OWSelectGenes.SelectCustom)
        group.buttonClicked[int].connect(self._selectionSourceChanged)

        if self.selectedSource == OWSelectGenes.SelectInput:
            button1.setChecked(True)
        else:
            button2.setChecked(True)

        self.entrybox = gui.widgetBox(box, None)
        offset = radio_indicator_width(button2)
        self.entrybox.layout().setContentsMargins(offset, 0, 0, 0)

        self.entrybox.setEnabled(
            self.selectedSource == OWSelectGenes.SelectCustom)

        box = gui.widgetBox(self.entrybox, "Select Genes")
        box.setFlat(True)
        box.setToolTip("Enter gene names to select")
        box.layout().setSpacing(1)

        self.entryField = ListTextEdit(box)
        self.entryField.setTabChangesFocus(True)
        self.entryField.setDocument(self._createDocument())
        self.entryField.itemsChanged.connect(self._onItemsChanged)

        box.layout().addWidget(self.entryField)

        completer = ListCompleter(self)
        completer.setCompletionMode(QCompleter.PopupCompletion)
        completer.setCompletionRole(
            self.CompletionRole if self.completeOnSymbols else Qt.DisplayRole
        )
        completer.setCaseSensitivity(Qt.CaseInsensitive)
        completer.setMaxVisibleItems(10)

        popup = QTreeView()
        popup.setSelectionMode(QTreeView.ExtendedSelection)
        popup.setEditTriggers(QTreeView.NoEditTriggers)
        popup.setRootIsDecorated(False)
        popup.setAlternatingRowColors(True)
        popup.setVerticalScrollBarPolicy(Qt.ScrollBarAlwaysOn)
        popup.setMaximumWidth(500)
        popup.header().setStretchLastSection(False)
        popup.header().hide()

        completer.setPopup(popup)
        completer.setModel(SetFilterProxyModel())

        self.entryField.setCompleter(completer)

        toolbar = QFrame()
        toolbar.setSizePolicy(QSizePolicy.MinimumExpanding, QSizePolicy.Fixed)
        layout = QHBoxLayout()
        layout.setContentsMargins(0, 0, 0, 0)
        layout.setSpacing(1)

        addaction = QAction("+", self)
        addmenu = QMenu()

        action = addmenu.addAction("Import names from gene sets...")
        action.triggered.connect(self.importGeneSet)

        action = addmenu.addAction("Import names from text file...")
        action.triggered.connect(self.importFromFile)

        addaction.setMenu(addmenu)

        def button(action, popupMode=None):
            b = QToolButton()
            b.setDefaultAction(action)
            if popupMode is not None:
                b.setPopupMode(QToolButton.InstantPopup)
            return b

        b = button(addaction, popupMode=QToolButton.InstantPopup)
        layout.addWidget(b)

        moreaction = QAction("More", self)

        moremenu = QMenu()
        self.completeOnSymbolsAction = QAction(
            "Complete on gene symbol names", self,
            toolTip="Use symbol names for auto completion.",
            checkable=True,
        )
        self.completeOnSymbolsAction.setChecked(self.completeOnSymbols)
        self.completeOnSymbolsAction.toggled[bool].connect(
            self._onToggleSymbolCompletion
        )

        moremenu.addAction(self.completeOnSymbolsAction)

        self.translateAction = QAction(
            "Translate all names to official symbol names", self,
            enabled=False
        )
        self.translateAction.triggered.connect(self._onTranslate)

        moremenu.addAction(self.translateAction)
        moreaction.setMenu(moremenu)

        b = button(moreaction, popupMode=QToolButton.InstantPopup)
        layout.addWidget(b)

        self.organismsCombo = ComboBox(focusPolicy=Qt.StrongFocus)
        self.organismsCombo.addItem("...")
        self.organismsCombo.model().item(0).setEnabled(False)
        self.organismsCombo.setMinimumWidth(200)
        self.organismsCombo.activated[int].connect(self._onOrganismActivated)

        layout.addSpacing(10)
        layout.addWidget(self.organismsCombo)
        self.pb = QProgressBar()
        self.pb.hide()
        self.pbstack = QStackedWidget()
        self.pbstack.addWidget(self.pb)

        layout.addSpacing(10)
        layout.addWidget(self.pbstack, 0, Qt.AlignRight | Qt.AlignVCenter)
        toolbar.setLayout(layout)

        box.layout().addWidget(toolbar)

        box = gui.widgetBox(self.entrybox, "Saved Selections")
        box.setFlat(True)
        box.setToolTip("Save/Select/Update saved gene selections")
        box.layout().setSpacing(1)

        self.selectionsModel = QStandardItemModel(self)
        self.selectionsView = QListView()
        self.selectionsView.setAlternatingRowColors(True)
        self.selectionsView.setModel(self.selectionsModel)
        self.selectionsView.setItemDelegate(SavedSlotDelegate(self))
        self.selectionsView.selectionModel().selectionChanged.connect(
            self._onSelectedSaveSlotChanged
        )

        box.layout().addWidget(self.selectionsView)

        self.actionSave = QAction(
            "Save", self,
            toolTip="Save/Update the current selection")

        self.actionAdd = QAction(
            "+", self,
            toolTip="Create a new saved selection")

        self.actionRemove = QAction(
            "\u2212", self,
            toolTip="Delete the current saved selection")

        toolbar = QFrame()
        layout = QHBoxLayout()
        layout.setContentsMargins(0, 0, 0, 0)
        layout.setSpacing(1)

        b = button(self.actionAdd)
        layout.addWidget(b)

        b = button(self.actionRemove)
        layout.addWidget(b)

        b = button(self.actionSave)
        layout.addWidget(b)

        layout.addStretch(100)
        toolbar.setLayout(layout)

        box.layout().addWidget(toolbar)

        self.actionSave.triggered.connect(self.saveSelection)
        self.actionAdd.triggered.connect(self.addSelection)
        self.actionRemove.triggered.connect(self.removeSelection)

        box = gui.widgetBox(self.controlArea, "Output")
        gui.checkBox(box, self, "preserveOrder", "Preserve input order",
                     tooltip="Preserve the order of the input data "
                             "instances.",
                     callback=self.invalidateOutput)
        gui.auto_commit(box, self, "autoCommit", "Commit", box=None)
#         cb = gui.checkBox(box, self, "autoCommit", "Auto commit")
#         button = gui.button(box, self, "Commit", callback=self.commit)
#         gui.setStopper(self, button, cb, "_changedFlag", self.commit)

        # Gene set import dialog (initialized when required)
        self._genesetDialog = None

        # restore saved selections model.
        for name, names in self.savedSelections:
            item = SaveSlot(name, names)
            self.selectionsModel.appendRow([item])

        if self.selectedSelectionIndex != -1:
            self.selectionsView.selectionModel().select(
                self.selectionsModel.index(self.selectedSelectionIndex, 0),
                QItemSelectionModel.Select
            )

        self._updateActions()

        def list_available_organisms():
            return [(taxid, taxonomy.name(taxid))
                    for taxid in taxonomy.common_taxids()]

        self._inittask = Task(function=list_available_organisms)

        self._inittask.finished.connect(self._onInit)
        self._executor.submit(self._inittask)
        self.pb.show()
        self.pb.setRange(0, 0)

    def _onInit(self):
        self.organisms = self._inittask.result()
        self.organismsCombo.clear()
        self.organismsCombo.addItems([name for _, name in self.organisms])

        self.taxidindex = \
            {taxid: i for i, (taxid, _) in enumerate(self.organisms)}

        self.organismsCombo.setCurrentIndex(
            self.taxidindex.get(self.taxid, -1))

        self.pb.hide()

        if self.taxid in self.taxidindex:
            self._updateGeneInfo()

    def _updateGeneInfo(self):
        self.geneinfo = (self.taxid, None)
        self.translateAction.setEnabled(False)

        if self._infotask:
            # Try to cancel existing pending task
            self._infotask.future().cancel()
            self._infotask.resultReady.disconnect(self._onGeneInfoReady)
            self._infotask.exceptionReady.disconnect(self._onGeneInfoError)

        def ncbi_gene_info(taxid=self.taxid):
            try:
                return (taxid, geneinfo.NCBIGeneInfo(taxid))
            except BaseException:
                sys.excepthook(*sys.exc_info())
                raise

        task = Task(function=ncbi_gene_info)
        task.resultReady.connect(self._onGeneInfoReady)
        task.exceptionReady.connect(self._onGeneInfoError)
        self._infotask = task
        self._executor.submit(task)
        self.pb.show()

    def _onOrganismActivated(self, index):
        try:
            taxid, _ = self.organisms[index]
        except IndexError:
            pass
        else:
            if taxid != self.taxid:
                self.taxid = taxid
                self._updateGeneInfo()

    def setData(self, data):
        """
        Set the input data.
        """
        self.closeContext()
        self.warning(0)
        self.data = data
        if data is not None:
            attrs = gene_candidates(data)
            self.variables[:] = attrs
            self.attrsCombo.setCurrentIndex(0)
            if attrs:
                self.geneIndex = 0
            else:
                self.geneIndex = -1
                self.warning(0, "No suitable columns for gene names.")
        else:
            self.variables[:] = []
            self.geneIndex = -1

        self._changedFlag = True

        oldtaxid = self.taxid
        if data is not None:
            self.taxid = data_hints.get_hint(data, "taxid", None)
        else:
            self.taxid = None

        self.openContext(data)

        if self.taxid is None:
            self.geneinfo = (None, None)

        if oldtaxid != self.taxid:
            self.organismsCombo.setCurrentIndex(
                self.taxidindex.get(self.taxid, -1))

            if self.taxid in self.taxidindex:
                self._updateGeneInfo()

        self._updateCompletionModel()

        self.commit()

    def setGeneSubset(self, data):
        """
        Set the gene subset input.
        """
        # TODO: In Orange 2 we had two context handlers. This is no
        # longer possible in Orange3.
#         self.closeContext("subset")
        self.warning(1)
        self.subsetData = data
        if data is not None:
            variables = gene_candidates(data)
            self.subsetVariables[:] = variables
            self.subsetVarCombo.setCurrentIndex(0)
            if variables:
                self.subsetGeneIndex = 0
            else:
                self.subsetGeneIndex = -1
                self.warning(1, "No suitable column for subset gene names.")
        else:
            self.subsetVariables[:] = []
            self.subsetGeneIndex = -1

#         self.openContext("subset", data)

        if self.selectedSource == OWSelectGenes.SelectInput:
            self.commit()

    @property
    def geneVar(self):
        """
        Current gene attribute or None if none available.
        """
        index = self.attrsCombo.currentIndex()
        if self.data is not None and index >= 0:
            return self.variables[index]
        else:
            return None

    @property
    def subsetGeneVar(self):
        """
        Current subset gene attribute or None if not available.
        """
        index = self.subsetVarCombo.currentIndex()
        if self.subsetData is not None and index >= 0:
            return self.subsetVariables[index]
        else:
            return None

    def invalidateOutput(self):
        if self.autoCommit:
            self.commit()
        else:
            self._changedFlag = True

    def selectedGenes(self):
        """
        Return the names of the currently selected genes.
        """
        selection = []
        if self.selectedSource == OWSelectGenes.SelectInput:
            var = self.subsetGeneVar
            if var is not None:
                assert isinstance(var, Orange.data.StringVariable)
                values = [inst[var] for inst in self.subsetData]
                selection = [str(val) for val in values if not math.isnan(val)]
        else:
            selection = self.selection
        return selection

    def commit(self):
        """
        Send the selected data subset to the output.
        """
        selection = self.selectedGenes()

        if self.geneinfo[1] is not None:
            backmap = dict((info.symbol, name) for name, info in self.genes
                           if info is not None)
            selection = [backmap.get(name, name) for name in selection]
        if self.geneVar is not None:
            data = select_by_genes(self.data, self.geneVar,
                                   gene_list=selection,
                                   preserve_order=self.preserveOrder)
        else:
            data = None

        self.send("Selected Data", data)
        self._changedFlag = False

    def setSelectionSource(self, source):
        if self.selectedSource != source:
            self.selectedSource = source
            self.subsetbox.setEnabled(source == OWSelectGenes.SelectInput)
            self.entrybox.setEnabled(source == OWSelectGenes.SelectCustom)
            b = self.selectedSourceButtons.button(source)
            b.setChecked(True)

    def _selectionSourceChanged(self, source):
        if self.selectedSource != source:
            self.selectedSource = source
            self.subsetbox.setEnabled(source == OWSelectGenes.SelectInput)
            self.entrybox.setEnabled(source == OWSelectGenes.SelectCustom)
            self.invalidateOutput()

    def _updateCompletionModel(self):
        var = self.geneVar
        if var is not None:
            assert isinstance(var, Orange.data.StringVariable)
            names, _ = self.data.get_column_view(var)
            if names.dtype == object:
                names = [name for name in names if isinstance(name, str)]
            elif names.dtype.kind in ["U", "S"]:
                names = [str(name) for name in names]
            else:
                raise TypeError
        else:
            names = []

        infodict = {}

        if self.geneinfo[1] is not None:
            info = [(name, self.geneinfo[1].get_info(name, None))
                    for name in names]
            info = filter(itemgetter(1), info)
            infodict = dict(info)

        names = sorted(set(names))
        genes = list(zip(names, map(infodict.get, names)))

        symbols = [info.symbol for _, info in genes if info is not None]

        model = QStandardItemModel()

        def make_row(name, info):
            if info is not None:
                col1 = QStandardItem(name)
                col1.setData(info.symbol, OWSelectGenes.CompletionRole)
                return [col1,
                        QStandardItem(info.symbol),
                        QStandardItem(info.description)]
            else:
                col1 = QStandardItem(name)
                col1.setData(name, OWSelectGenes.CompletionRole)
                return [col1]

        for name, info in genes:
            model.appendRow(make_row(name, info))

        self.geneNames = sorted(set(names) | set(symbols))
        self.genes = genes

        self.entryField.completer().model().setSourceModel(model)
        self.entryField.document().highlighter.setNames(names + symbols)

        self._updatePopupSections()

    def _onGeneIndexChanged(self):
        self._updateCompletionModel()
        self.invalidateOutput()

    def _onSubsetGeneIndexChanged(self):
        if self.selectedSource == OWSelectGenes.SelectInput:
            self.invalidateOutput()

    def _onItemsChanged(self, names):
        selection = set(names).intersection(self.geneNames)
        curr_selection = set(self.selection).intersection(self.geneNames)

        self.selection = names

        if selection != curr_selection:
            self.invalidateOutput()
            to_complete = sorted(set(self.geneNames) - set(names))
            self.entryField.completer().model().setFilterFixedSet(to_complete)

        item = self._selectedSaveSlot()
        if item:
            item.modified = item.savedata != names

    def _onToggleSymbolCompletion(self, state):
        completer = self.entryField.completer()
        completer.setCompletionRole(
            self.CompletionRole if state else Qt.DisplayRole
        )
        self.completeOnSymbols = state
        self._updatePopupSections()

    def _onTranslate(self):
        if self.geneinfo[1] is not None:
            items = self.entryField.items()
            entries = map(self.geneinfo[1].get_info, items)
            items = [info.symbol if info is not None else item
                     for item, info in zip(items, entries)]
            self.entryField.selectAll()
            self.entryField.insertPlainText(" ".join(items))

    def _onGeneInfoReady(self, geneinfo):
        assert QThread.currentThread() is self.thread()
        # Check if the gene info is for the correct (current requested)
        # organism (we might receive a late response from a previous
        # request)
        if self.geneinfo[0] == geneinfo[0]:
            self.geneinfo = geneinfo
            self.translateAction.setEnabled(True)
            self.pb.hide()
            self._updateCompletionModel()

    def _onGeneInfoError(self, exc):
        self.error(0, str(exc))

    def _updatePopupSections(self):
        completer = self.entryField.completer()
        popup = completer.popup()
        assert isinstance(popup, QTreeView)
        header = popup.header()
        # The column in which the symbols should be
        symbol_col = 0 if self.completeOnSymbols else 1
        if symbol_col != header.sectionPosition(1):
            header.moveSection(0, 1)

    def _selectedSaveSlot(self):
        """
        Return the current selected saved selection slot.
        """
        indexes = self.selectionsView.selectedIndexes()
        if indexes:
            return self.selectionsModel.item(indexes[0].row())
        else:
            return None

    def saveSelection(self):
        """
        Save (update) the items in the current selected selection.
        """
        item = self._selectedSaveSlot()
        if item:
            item.savedata = self.entryField.items()
            item.modified = False

    def copyToSaved(self):
        """
        Copy the current 'Gene Subset' names to saved selections.
        """
        if self.subsetGeneVar and \
                self.selectedSource == OWSelectGenes.SelectInput:
            names = self.selectedGenes()
            item = SaveSlot("New selection")
            item.savedata = names
            self.selectionsModel.appendRow([item])
            self.setSelectionSource(OWSelectGenes.SelectCustom)
            self.selectionsView.setCurrentIndex(item.index())
            self.selectionsView.edit(item.index())

    def appendToSelected(self):
        """
        Append the current 'Gene Subset' names to 'Select Genes' entry field.
        """
        if self.subsetGeneVar and \
                self.selectedSource == OWSelectGenes.SelectInput:
            names = self.selectedGenes()
            text = " ".join(names)
            self.entryField.appendPlainText(text)
            self.setSelectionSource(OWSelectGenes.SelectCustom)
            self.entryField.setFocus()
            self.entryField.moveCursor(QTextCursor.End)

    def addSelection(self, name=None):
        """
        Add a new saved selection entry initialized by the current items.

        The new slot will be selected.

        """
        item = SaveSlot(name or "New selection")
        item.savedata = self.entryField.items()
        self.selectionsModel.appendRow([item])
        self.selectionsView.setCurrentIndex(item.index())

        if not name:
            self.selectionsView.edit(item.index())

    def removeSelection(self):
        """
        Remove the current selected save slot.
        """
        item = self._selectedSaveSlot()
        if item:
            self.selectionsModel.removeRow(item.row())

    def importGeneSet(self):
        if self._genesetDialog is None:
            self._genesetDialog = GeneSetDialog(
                self, windowTitle="Import Gene Set Names")

        dialog = self._genesetDialog

        if self.taxid is not None:
            dialog.setCurrentOrganism(self.taxid)

        result = dialog.exec_()
        if result == QDialog.Accepted:
            gsets = dialog.selectedGeneSets()
            genes = reduce(operator.ior, (gs.genes for gs in gsets), set())
            text = " ".join(genes)
            self.entryField.appendPlainText(text)
            self.entryField.setFocus()
            self.entryField.moveCursor(QTextCursor.End)

    def importFromFile(self):
        filename, _ = QFileDialog.getOpenFileName(
            self, "Open File", os.path.expanduser("~/"))

        if filename:
            with open(filename, "rU") as f:
                text = f.read()
            self.entryField.appendPlainText(text)
            self.entryField.setFocus()
            self.entryField.moveCursor(QTextCursor.End)

    def _onSelectedSaveSlotChanged(self):
        item = self._selectedSaveSlot()
        if item:
            if not item.document:
                item.document = self._createDocument()
                if item.savedata:
                    item.document.setPlainText(" ".join(item.savedata))

            item.document.highlighter.setNames(self.geneNames)

            self.entryField.setDocument(item.document)

        self._updateActions()

    def _createDocument(self):
        """
        Create and new QTextDocument instance for editing gene names.
        """
        doc = QTextDocument(self)
        doc.setDocumentLayout(QPlainTextDocumentLayout(doc))
        doc.highlighter = NameHighlight(doc)
        return doc

    def _updateActions(self):
        """
        Update the Save/remove action enabled state.
        """
        selected = bool(self._selectedSaveSlot())
        self.actionRemove.setEnabled(selected)
        self.actionSave.setEnabled(selected)

    def getSettings(self, *args, **kwargs):
        # copy the saved selections model back to widget settings.
        selections = []
        for i in range(self.selectionsModel.rowCount()):
            item = self.selectionsModel.item(i)
            selections.append((item.name, item.savedata))
        self.savedSelections = selections

        item = self._selectedSaveSlot()
        if item is None:
            self.selectedSelectionIndex = -1
        else:
            self.selectedSelectionIndex = item.row()

        return OWWidget.getSettings(self, *args, **kwargs)

#     def sendReport(self):
#         report = []
#         if self.data is not None:
#             report.append("%i instances on input." % len(self.data))
#         else:
#             report.append("No data on input.")
# 
#         if self.geneVar is not None:
#             report.append("Gene names taken from %r attribute." %
#                           escape(self.geneVar.name))
# 
#         self.reportSection("Input")
#         self.startReportList()
#         for item in report:
#             self.addToReportList(item)
#         self.finishReportList()
#         report = []
#         selection = self.selectedGenes()
#         if self.selectedSource == OWSelectGenes.SelectInput:
#             self.reportRaw(
#                 "<p>Gene Selection (from 'Gene Subset' input): %s</p>" %
#                 escape(" ".join(selection))
#             )
#         else:
#             self.reportRaw(
#                 "<p>Gene Selection: %s</p>" %
#                 escape(" ".join(selection))
#             )
#         self.reportSettings(
#             "Settings",
#             [("Preserve order", self.preserveOrder)]
#         )

    def onDeleteWidget(self):
        self._inittask.future().cancel()

        if self._infotask:
            self._infotask.future().cancel()

        self._executor.shutdown(wait=True)
        super().onDeleteWidget()


def is_string(var):
    return isinstance(var, Orange.data.StringVariable)


def domain_variables(domain):
    """
    Return all feature descriptors from the domain.
    """
    return domain.variables + domain.metas


def gene_candidates(data):
    """
    Return features that could contain gene names.
    """
    return list(filter(is_string, domain_variables(data.domain)))


def select_by_genes(data, gene_feature, gene_list, preserve_order=True):
    if preserve_order:
        selection = set(gene_list)
        sel = [i for i, inst in enumerate(data)
               if str(inst[gene_feature]) in selection]
    else:
        by_genes = defaultdict(list)
        for i, inst in enumerate(data):
            by_genes[str(inst[gene_feature])].append(i)

        sel = []
        for name in gene_list:
            sel.extend(by_genes.get(name, []))

    return data.from_table(data.domain, data, sel)


_CompletionState = namedtuple(
    "_CompletionState",
    ["start",   # completion prefix start position
     "pos",     # cursor position
     "anchor"]  # anchor position (inline completion end)
)


class ListTextEdit(QPlainTextEdit):
    """
    A text editor specialized for editing a list of items.
    """
    #: Emitted when the list items change.
    itemsChanged = Signal(list)

    def __init__(self, parent=None, **kwargs):
        QPlainTextEdit.__init__(self, parent, **kwargs)

        self._items = None
        self._completer = None
        self._completionState = _CompletionState(-1, -1, -1)

        self.cursorPositionChanged.connect(self._cursorPositionChanged)
        self.textChanged.connect(self._textChanged)

    def setCompleter(self, completer):
        """
        Set a completer for list items.
        """
        if self._completer is not None:
            self._completer.setWidget(None)
            self._completer.activated.disconnect(self._insertCompletion)

        self._completer = completer

        if self._completer:
            self._completer.setWidget(self)
            self._completer.activated.connect(self._insertCompletion)

    def completer(self):
        """
        Return the completer.
        """
        return self._completer

    def setItems(self, items):
        text = " ".join(items)
        self.setPlainText(text)

    def items(self):
        if self._items is None:
            self._items = self._getItems()
        return self._items

    def keyPressEvent(self, event):
        # TODO: in Qt 4.8 QPlainTextEdit uses inputMethodEvent for
        # non-ascii input

        if self._completer.popup().isVisible():
            if event.key() in [Qt.Key_Enter, Qt.Key_Return, Qt.Key_Escape,
                               Qt.Key_Tab, Qt.Key_Backtab]:
                # These need to propagate to the completer.
                event.ignore()
                return

        QPlainTextEdit.keyPressEvent(self, event)

        if not len(event.text()) or not is_printable(event.text()[0]):
            return

        text = self.toPlainText()
        cursor = self.textCursor()
        pos = cursor.position()

        if pos == len(text) or not text[pos].strip():
            # cursor is at end of text or whitespace
            # find the beginning of the current word
            whitespace = " \t\n\r\f\v"
            start = max([text.rfind(c, 0, pos) for c in whitespace]) + 1

            prefix = text[start:pos]

            if prefix:
                if self._completer.completionPrefix() != prefix:
                    self._completer.setCompletionPrefix(text[start:pos])

                rect = self.cursorRect()
                popup = self._completer.popup()
                if popup.isVisible():
                    rect.setWidth(popup.width())
                else:
                    view_adjust_size_to_contents(popup)
                    rect.setWidth(popup.width())

                # Popup the completer list
                self._completer.complete(rect)

                # Inline completion of a common prefix
                inline = self._commonCompletionPrefix()
                inline = inline[len(prefix):]

                self._completionState = \
                    _CompletionState(start, pos, pos + len(inline))

                cursor.insertText(inline)
                cursor.setPosition(pos, QTextCursor.KeepAnchor)
                self.setTextCursor(cursor)

            elif self._completer.popup().isVisible():
                self._stopCompletion()

    def _cursorPositionChanged(self):
        cursor = self.textCursor()
        pos = cursor.position()
        start, _, _ = self._completionState

        if start == -1:
            # completion not in progress
            return

        if pos <= start:
            # cursor moved before the start of the prefix
            self._stopCompletion()
            return

        text = self.toPlainText()
        # Find the end of the word started by completion prefix
        word_end = len(text)
        for i in range(start, len(text)):
            if text[i] in " \t\n\r\f\v":
                word_end = i
                break

        if pos > word_end:
            # cursor moved past the word boundary
            self._stopCompletion()

        # TODO: Update the prefix when moving the cursor
        # inside the word

    def _insertCompletion(self, item):
        if isinstance(item, list):
            completion = " ".join(item)
        else:
            completion = item

        start, _, end = self._completionState

        self._stopCompletion()

        cursor = self.textCursor()
        # Replace the prefix+inline with the full completion
        # (correcting for the case-insensitive search).
        cursor.setPosition(min(end, self.document().characterCount()))
        cursor.setPosition(start, QTextCursor.KeepAnchor)

        cursor.insertText(completion + " ")

    def _commonCompletionPrefix(self):
        """
        Return the common prefix of items in the current completion model.
        """
        model = self._completer.completionModel()
        column = self._completer.completionColumn()
        role = self._completer.completionRole()
        items = [str(model.index(i, column).data(role))
                 for i in range(model.rowCount())]
        if not items:
            return ""

        first = min(items)
        last = max(items)
        for i, c in enumerate(first):
            if c != last[i]:
                return first[:i]

        return first

    def _stopCompletion(self):
        self._completionState = _CompletionState(-1, -1, -1)
        if self._completer.popup().isVisible():
            self._completer.popup().hide()

    def _textChanged(self):
        items = self._getItems()
        if self._items != items:
            self._items = items
            self.itemsChanged.emit(items)

    def _getItems(self):
        """
        Return the current items (a list of strings).

        .. note:: The inline completion text is not included.

        """
        text = self.toPlainText()
        if self._completionState[0] != -1:
            # Remove the inline completion text
            _, pos, end = self._completionState
            text = text[:pos] + text[end:]
        return [item for item in text.split() if item.strip()]


def view_adjust_column_sizes(view, max_width=None):
    """
    Adjust view's column sizes to to contents.
    """
    if max_width is None:
        max_width = sys.maxsize

    for col in range(view.model().columnCount()):
        width = min(view.sizeHintForColumn(col), max_width)
        view.setColumnWidth(col, width)


def view_adjust_size_to_contents(view):
    """
    Adjust the view to a reasonable size based in it's contents.
    """
    view_adjust_column_sizes(view)
    w = sum([view.columnWidth(col)
             for col in range(view.model().columnCount())])
    w += view.verticalScrollBar().sizeHint().width()

    h = view.sizeHintForRow(0) * 7
    h += view.horizontalScrollBar().sizeHint().height()
    view.resize(w, h)


class NameHighlight(QSyntaxHighlighter):
    def __init__(self, parent=None, **kwargs):
        super(NameHighlight, self).__init__(parent, **kwargs)

        self._names = set()

        self._format = QTextCharFormat()
        self._format.setForeground(Qt.blue)

        self._unrecognized_format = QTextCharFormat()
#         self._unrecognized_format.setFontStrikeOut(True)

    def setNames(self, names):
        self._names = set(names)
        self.rehighlight()

    def names(self):
        return set(self._names)

    def highlightBlock(self, text):
        pattern = re.compile(r"\S+")
        for match in pattern.finditer(text):
            name = text[match.start(): match.end()]
            match_len = match.end() - match.start()

            if not name.strip():
                continue

            if name in self._names:
                charfmt = self._format
            else:
                charfmt = self._unrecognized_format

            self.setFormat(match.start(), match_len, charfmt)


@contextmanager
def signals_blocked(obj):
    blocked = obj.signalsBlocked()
    obj.blockSignals(True)
    try:
        yield
    finally:
        obj.blockSignals(blocked)


class ListCompleter(QCompleter):
    """
    A completer supporting selection of multiple list items.
    """
    activated = Signal(list)

    def __init__(self, *args, **kwargs):
        QCompleter.__init__(self, *args, **kwargs)

        popup = QListView()
        popup.setEditTriggers(QListView.NoEditTriggers)
        popup.setSelectionMode(QListView.ExtendedSelection)

        self.setPopup(popup)

    def setPopup(self, popup):
        QCompleter.setPopup(self, popup)

        popup.viewport().installEventFilter(self)
        popup.doubleClicked.connect(self._complete)

    def eventFilter(self, receiver, event):
        if event.type() == QEvent.KeyPress and receiver is self.popup():
            if event.key() in [Qt.Key_Enter, Qt.Key_Return, Qt.Key_Tab]:
                self._complete()
                return True

        elif event.type() == QEvent.MouseButtonRelease and \
                receiver is self.popup().viewport():
            # Process the event without emitting 'clicked', ... signal to
            # override the default QCompleter behavior
            with signals_blocked(self.popup()):
                QApplication.sendEvent(self.popup(), event)
                return True

        return QCompleter.eventFilter(self, receiver, event)

    def _complete(self):
        column = self.completionColumn()
        role = self.completionRole()
        indexes = self.popup().selectionModel().selectedRows(column)

        items = [str(index.data(role)) for index in indexes]

        if self.popup().isVisible():
            self.popup().hide()

        if items:
            self.activated.emit(items)


class SetFilterProxyModel(QSortFilterProxyModel):
    def __init__(self, *args, **kwargs):
        super(SetFilterProxyModel, self).__init__(*args, **kwargs)
        self._filterFixedSet = None

    def setFilterFixedSet(self, items):
        if items is None:
            self._filterFixedSet = None
        else:
            self._filterFixedSet = set(items)
        self.invalidateFilter()

    def filterAcceptsRow(self, row, parent):
        if self._filterFixedSet is None:
            return True

        model = self.sourceModel()
        col = self.filterKeyColumn()
        var = model.data(model.index(row, col, parent),
                         self.filterRole())
        var = str(var)
        return var in self._filterFixedSet


class ComboBox(QComboBox):
    """
    A combo box ignoring mouse wheel events.
    """
    def wheelEvent(self, event):
        event.ignore()
        return

# All control character categories.
_control = set(["Cc", "Cf", "Cs", "Co", "Cn"])


def is_printable(unichar):
    """
    Return True if the unicode character `unichar` is a printable character.
    """
    return unicodedata.category(unichar) not in _control

import itertools

from AnyQt.QtWidgets import (
    QVBoxLayout, QLineEdit, QDialogButtonBox, QProgressBar, QSizePolicy
)
from AnyQt.QtCore import QSize
from orangecontrib.bio import geneset as genesets
from orangecontrib.bio.utils import serverfiles


class GeneSetView(QFrame):
    selectedOrganismChanged = Signal(str)
    selectionChanged = Signal()
    geneSetsLoaded = Signal()

    def __init__(self, *args, **kwargs):
        super(GeneSetView, self).__init__(*args, **kwargs)

        self._taxid = None

        layout = QVBoxLayout()
        layout.setContentsMargins(0, 0, 0, 0)

        self._stack = QStackedWidget()
        self._stack.setContentsMargins(0, 0, 0, 0)
        self._stack.setSizePolicy(QSizePolicy.MinimumExpanding,
                                  QSizePolicy.Fixed)
        self.orgcombo = ComboBox(minimumWidth=150, focusPolicy=Qt.StrongFocus)
        self.orgcombo.activated[int].connect(self._on_organismSelected)
        self._stack.addWidget(self.orgcombo)

        self.progressbar = QProgressBar()
        self._stack.addWidget(self.progressbar)

        layout.addWidget(self._stack)

        self.searchline = QLineEdit()
        self.searchline.setPlaceholderText("Filter...")
        completer = QCompleter()
        self.searchline.setCompleter(completer)
        layout.addWidget(self.searchline)

        self.gsview = QTreeView()
        self.gsview.setAlternatingRowColors(True)
        self.gsview.setRootIsDecorated(False)
        self.gsview.setSelectionMode(QTreeView.ExtendedSelection)
        self.gsview.setSortingEnabled(True)
        self.gsview.setUniformRowHeights(True)
        self.proxymodel = QSortFilterProxyModel(
            self, filterKeyColumn=1, sortCaseSensitivity=Qt.CaseInsensitive
        )

        self.gsview.setModel(self.proxymodel)
        self.gsview.selectionModel().selectionChanged.connect(
            self._on_selectionChanged)

        self.searchline.textChanged.connect(
            self.proxymodel.setFilterFixedString)

        layout.addWidget(self.gsview)
        self.setLayout(layout)

        self._executor = ThreadExecutor(self)
        self.initialize()

    def initialize(self):
        gs = genesets.list_all()
        # Filter out genesets with taxid == None
        # (What the furious felonious ferrous ferrets)
        gs = [(h, taxid, _2) for h, taxid, _2 in gs if taxid]

        self.gs_hierarchy = gs
        taxids = set(taxid for _, taxid, _ in gs)
        self.organisms = [(taxid, taxonomy.name(taxid)) for taxid in taxids]
        for taxid, name in self.organisms:
            self.orgcombo.addItem(name, taxid)

        self.orgcombo.setCurrentIndex(-1)

    def sizeHint(self):
        return QSize(500, 550)

    def setCurrentOrganism(self, taxid):
        taxids = [tid for tid, _ in self.organisms]
        if taxid is not None and taxid not in taxids:
            taxid = None

        if taxid != self._taxid:
            self._taxid = taxid
            if taxid is None:
                self.orgcombo.setCurrentIndex(-1)
            else:
                index = taxids.index(taxid)
                self.orgcombo.setCurrentIndex(index)
            self._updateGeneSetsModel()
            self.selectedOrganismChanged.emit(taxid)

    def currentOrganism(self):
        return self._taxid

    def selectedGeneSets(self):
        selmod = self.gsview.selectionModel()
        model = self.proxymodel.sourceModel()
        rows = [self.proxymodel.mapToSource(row)
                for row in selmod.selectedRows(1)]
        gsets = [model.data(row, Qt.UserRole) for row in rows]
        return gsets

    def _updateGeneSetsModel(self):
        taxid = self._taxid
        if taxid is None:
            self.proxymodel.setSourceModel(None)
        else:
            currentsets = [(hier, tid)
                           for hier, tid, _ in self.gs_hierarchy
                           if tid == taxid]

            gsmissing = [(hier, tid, local)
                         for hier, tid, local in self.gs_hierarchy
                         if tid == taxid and not local]

            self._stack.setCurrentWidget(self.progressbar)

            if gsmissing:
                self.progressbar.setRange(0, 100)
                progress_info = methodinvoke(
                    self.progressbar, "setValue", (int,))
            else:
                self.progressbar.setRange(0, 0)
                progress_info = None

            def load():
                gs_ensure_downloaded(
                    gsmissing,
                    progress_info=progress_info)

                return [((hier, tid), genesets.load(hier, tid))
                        for hier, tid in currentsets]

            self._task = Task(function=load)
            self._task.finished.connect(self._on_loadFinished)
            self._executor.submit(self._task)

    def _on_loadFinished(self):
        assert QThread.currentThread() is self.thread()
        self._stack.setCurrentWidget(self.orgcombo)

        try:
            sets = self._task.result()
        except Exception:
            # Should do something better here.
            sys.excepthook(*sys.exc_info())
            sets = []

        model = sets_to_model(sets)
        self.proxymodel.setSourceModel(model)
        self.gsview.resizeColumnToContents(0)
        self.geneSetsLoaded.emit()

    def _on_organismSelected(self, index):
        if index != -1:
            item = self.orgcombo.model().item(index)
            taxid = str(item.data(Qt.UserRole))
            self.setCurrentOrganism(taxid)

    def _on_selectionChanged(self, *args):
        self.selectionChanged.emit()


def sets_to_model(gsets):
    model = QStandardItemModel()
    model.setHorizontalHeaderLabels(["Category", "Name", "#"])

    for (hier, tid), sets in gsets:
        for gset in sets:
            ngenes = len(gset.genes)
            names = [escape(name) for name in list(gset.genes)[:30]]
            names = ", ".join(names)
            tooltip = "<p>{0}</p>{1}".format(escape(gset.name), names)
            if ngenes > 30:
                tooltip += ", ... ({0} names not shown)".format(ngenes - 30)

            category = QStandardItem(" ".join(hier))
            category.setData((hier, tid), Qt.UserRole)
            category.setEditable(False)
            category.setToolTip(tooltip)
            name = QStandardItem(gset.name)
            name.setData(gset, Qt.UserRole)
            name.setEditable(False)
            name.setToolTip(tooltip)
            count = QStandardItem()
            count.setData(ngenes, Qt.DisplayRole)
            count.setToolTip(tooltip)
            model.appendRow([category, name, count])

    return model


def gs_ensure_downloaded(gslist, progress_info=None):
    hierlist = [(hier, taxid) for hier, taxid, local in gslist
                if not local]

    files = [(genesets.sfdomain, genesets.filename(hier, taxid))
             for hier, taxid in hierlist]

    download_list(files, progress_info)


def download_list(files_list, progress_callback=None):
    nfiles = len(files_list)
    count = 100 * nfiles
    counter = itertools.count()

    def advance():
        progress_callback(100.0 * next(counter) / count)

    for domain, filename in files_list:
        serverfiles.download(domain, filename,
                             callback=advance if progress_callback else None)


class GeneSetDialog(QDialog):
    selectionChanged = Signal()

    def __init__(self, *args, **kwargs):
        super(GeneSetDialog, self).__init__(*args, **kwargs)
        layout = QVBoxLayout()
        layout.setContentsMargins(4, 4, 4, 4)
        self.gsview = GeneSetView()
        self.gsview.selectionChanged.connect(self.selectionChanged)

        layout.addWidget(self.gsview)

        buttonbox = QDialogButtonBox(
            QDialogButtonBox.Ok | QDialogButtonBox.Cancel,
            Qt.Horizontal
        )
        buttonbox.accepted.connect(self.accept)
        buttonbox.rejected.connect(self.reject)

        layout.addWidget(buttonbox)

        self.setLayout(layout)

    def selectedGeneSets(self):
        return self.gsview.selectedGeneSets()

    def setCurrentOrganism(self, taxid):
        self.gsview.setCurrentOrganism(taxid)

    def currentOrganism(self):
        return self.gsview.currentOrganism()


def test1():
    app = QApplication([])
    dlg = GeneSetDialog()
    dlg.show()
    dlg.raise_()
    dlg.exec_()
    del dlg
    app.processEvents()


def test():
    app = QApplication([])
    w = OWSelectGenes()
    data = Orange.data.Table("brown-selected")
    w.setData(data)
    w.setGeneSubset(Orange.data.Table(data[:10]))
    w.show()
    app.exec_()
    w.saveSettings()
    w.deleteLater()
    del w
    app.processEvents()

if __name__ == "__main__":
    test()
